Epidemiology study

The epidemiology research project (Project 2) is entitled, “Environmental and Genetic Determinants of Puberty.” This is a collaborative multi-site epidemiologic study of young girls experiencing physiologic changes of thelarche and sexual maturation and their exposures that can impact on their future risk of breast cancer, using standardized methodologies to collect data on markers of breast development and other physiologic changes of sexual maturation, assessment of environmental stressors of importance to future breast cancer risk, including lifestyle behaviors, nutrition and dietary supplements, anthropometry, chemical and physical exposures at home, and school, and social factors.

	Center	Project Lead	Anticipated Study Population
	Fox Chase Cancer Center	Mary Wolff, PhD Mt Sinai School of Medicine [email protected]	600 7- & 8-yr old girls from East Harlem 60% Latina, 40% African-American
	University of Cincinnati	Frank Biro, MD Cincinnati Children’s Hospital Medical Center [email protected]	400 6- & 7-yr old girls from greater Cincinnati metropolitan area (selected school districts in SW Ohio and Northern Kentucky) 65% white, 35% black
	San Francisco Bay Area	Lawrence Kushi, ScD Kaiser Permanente, Div of Research [email protected]	400 7-yr old girls, members of Kaiser Permanente, in San Francisco, Marin, and Alameda Counties 18% Asian, 9% Pacific Islander, 19% African-American, 20% Latina, 35% white